CN Patent

CN104650142B — 一种福沙匹坦二甲葡胺的制备方法

Assigned to Lunnan Better Pharmaceutical Co ltd · Expires 2018-06-22 · 8y expired

What this patent protects

本发明提供了一种福沙匹坦二甲葡胺的制备方法，以阿瑞匹坦为原料，在碱性条件下，通过膦酰化得到二苄酯中间体，并进一步将中间体水解得到福沙匹坦，进一步地与N‑甲基‑D‑葡糖胺反应，得到福沙匹坦二甲葡胺。本发明提供的方法操作简单，反应条件温和，避免加压氢化，安全有效，适合工业化大生产。

USPTO Abstract

本发明提供了一种福沙匹坦二甲葡胺的制备方法，以阿瑞匹坦为原料，在碱性条件下，通过膦酰化得到二苄酯中间体，并进一步将中间体水解得到福沙匹坦，进一步地与N‑甲基‑D‑葡糖胺反应，得到福沙匹坦二甲葡胺。本发明提供的方法操作简单，反应条件温和，避免加压氢化，安全有效，适合工业化大生产。

Drugs covered by this patent

Patent Metadata

Patent number
CN104650142B
Jurisdiction
CN
Classification
—
Expires
2018-06-22
Drug substance claim
No
Drug product claim
No
Assignee
Lunnan Better Pharmaceutical Co ltd
Source
FDA Orange Book + USPTO grounding via Google Patents

Bibliographic data sourced from FDA Orange Book + USPTO public records. Plain-English summary generated by AI grounded in source text. Patent term extensions (PTR, SPC, pediatric) may shift the effective expiry. Not legal advice.

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