CN104557943B — 一种维格列汀杂质的制备方法
Assigned to Sichuan Hairong Pharmaceutical Industry Co Ltd Of Yangzijiang Pharmaceutical · Expires 2017-05-03 · 9y expired
What this patent protects
本发明公开了一种维格列汀杂质的制备方法，通过将起始原料(S)‑N‑氯乙酰基‑2‑氰基吡咯烷和3‑氨基‑1‑金刚烷醇溶于溶剂后，在碱性条件与碘化钾的催化下反应制得中间产物(S)‑1‑[[(3‑羟基金刚烷)氨基]乙酰基]‑2‑氰基吡咯烷，再将中间产物于路易斯酸的催化下制得维格列汀杂质的方法制备维格列汀杂质。该制备方法过程简单，操作简便，有利于提高制备效率。
USPTO Abstract
本发明公开了一种维格列汀杂质的制备方法，通过将起始原料(S)‑N‑氯乙酰基‑2‑氰基吡咯烷和3‑氨基‑1‑金刚烷醇溶于溶剂后，在碱性条件与碘化钾的催化下反应制得中间产物(S)‑1‑[[(3‑羟基金刚烷)氨基]乙酰基]‑2‑氰基吡咯烷，再将中间产物于路易斯酸的催化下制得维格列汀杂质的方法制备维格列汀杂质。该制备方法过程简单，操作简便，有利于提高制备效率。
Drugs covered by this patent
Bibliographic data sourced from FDA Orange Book + USPTO public records. Plain-English summary generated by AI grounded in source text. Patent term extensions (PTR, SPC, pediatric) may shift the effective expiry. Not legal advice.
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