CN Patent

CN104478769B — 一种适合工业化生产的贝利司他合成方法

Assigned to WANLE PHARMACEUTICAL CO Ltd SHENZHEN · Expires 2016-01-06 · 10y expired

What this patent protects

本发明提供了一种改进的贝利司他的合成方法，该方法以间羧基苯磺酸钠为起始物料，经酯化、酰化及苯胺缩合、还原、氧化、Wittig-Horner缩合及水解、酰化及羟胺缩合6个步骤制备得到，该方法缩短了生产时间，提高了反应收率，且增强了生产的安全性并减少环境污染，更适合工业化生产。

USPTO Abstract

本发明提供了一种改进的贝利司他的合成方法，该方法以间羧基苯磺酸钠为起始物料，经酯化、酰化及苯胺缩合、还原、氧化、Wittig-Horner缩合及水解、酰化及羟胺缩合6个步骤制备得到，该方法缩短了生产时间，提高了反应收率，且增强了生产的安全性并减少环境污染，更适合工业化生产。

Drugs covered by this patent

Patent Metadata

Patent number
CN104478769B
Jurisdiction
CN
Classification
—
Expires
2016-01-06
Drug substance claim
No
Drug product claim
No
Assignee
WANLE PHARMACEUTICAL CO Ltd SHENZHEN
Source
FDA Orange Book + USPTO grounding via Google Patents

Bibliographic data sourced from FDA Orange Book + USPTO public records. Plain-English summary generated by AI grounded in source text. Patent term extensions (PTR, SPC, pediatric) may shift the effective expiry. Not legal advice.

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