CN Patent

CN104356112B — 一种色瑞替尼的制备方法

Assigned to Anqing Chico Pharmaceutical Co ltd · Expires 2017-03-15 · 9y expired

What this patent protects

本发明公开了一种色瑞替尼的制备方法，属于化学制药领域，以3‑溴‑4‑甲基苯酚为起始原料经过酚羟基异丙基化、硝化、偶联、还原反应得到中间体1，再以邻硝基氟苯为另一起始原料经异巯基化、氧化、还原、嘧啶化得中间体2，1与2偶联反应得BOC酸酐保护的色瑞替尼，最后脱除叔丁氧羰基保护基得到色瑞替尼。本发明是一种操作简单易行，收率比较高，污染小，适合工业化生产的方法。

USPTO Abstract

本发明公开了一种色瑞替尼的制备方法，属于化学制药领域，以3‑溴‑4‑甲基苯酚为起始原料经过酚羟基异丙基化、硝化、偶联、还原反应得到中间体1，再以邻硝基氟苯为另一起始原料经异巯基化、氧化、还原、嘧啶化得中间体2，1与2偶联反应得BOC酸酐保护的色瑞替尼，最后脱除叔丁氧羰基保护基得到色瑞替尼。本发明是一种操作简单易行，收率比较高，污染小，适合工业化生产的方法。

Drugs covered by this patent

Patent Metadata

Patent number
CN104356112B
Jurisdiction
CN
Classification
—
Expires
2017-03-15
Drug substance claim
No
Drug product claim
No
Assignee
Anqing Chico Pharmaceutical Co ltd
Source
FDA Orange Book + USPTO grounding via Google Patents

Bibliographic data sourced from FDA Orange Book + USPTO public records. Plain-English summary generated by AI grounded in source text. Patent term extensions (PTR, SPC, pediatric) may shift the effective expiry. Not legal advice.

Track this patent

Get a daily-checked alert when vulnerability score, expiry, classification, or assignee changes. Email, Slack, or Teams delivery. Pro: 50 watches, Free: 3.