CN Patent

CN104211663B — 一种(s)-n-甲氧基-甲基-2-(四氢吡咯基)丙酰胺及其制备方法和应用

Assigned to HANGZHOU OULIAN MEDICINE SCIENCE & TECHNOLOGY Co Ltd · Expires 2017-01-11 · 9y expired

What this patent protects

本发明公开了一种式(5)所示的(S)‑N‑甲氧基‑甲基‑2‑(四氢吡咯基)丙酰胺，其制备方法为：以L‑丙氨酸为起始原料，通过氨基保护、与N,O‑二甲基羟胺盐酸盐反应、脱除氨基保护基、烷基化四步反应制备得到；所得式(5)所示化合物再经加成消去、还原即得式(7)所示的依法韦伦手性配体；本发明中依法韦伦手性配体的合成方法具有反应条件温和、操作简便、收率高、生产成本低等优点，适合于工业化生产；

USPTO Abstract

本发明公开了一种式(5)所示的(S)‑N‑甲氧基‑甲基‑2‑(四氢吡咯基)丙酰胺，其制备方法为：以L‑丙氨酸为起始原料，通过氨基保护、与N,O‑二甲基羟胺盐酸盐反应、脱除氨基保护基、烷基化四步反应制备得到；所得式(5)所示化合物再经加成消去、还原即得式(7)所示的依法韦伦手性配体；本发明中依法韦伦手性配体的合成方法具有反应条件温和、操作简便、收率高、生产成本低等优点，适合于工业化生产；

Drugs covered by this patent

Patent Metadata

Patent number
CN104211663B
Jurisdiction
CN
Classification
—
Expires
2017-01-11
Drug substance claim
No
Drug product claim
No
Assignee
HANGZHOU OULIAN MEDICINE SCIENCE & TECHNOLOGY Co Ltd
Source
FDA Orange Book + USPTO grounding via Google Patents

Bibliographic data sourced from FDA Orange Book + USPTO public records. Plain-English summary generated by AI grounded in source text. Patent term extensions (PTR, SPC, pediatric) may shift the effective expiry. Not legal advice.

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