CN Patent

CN103910672B — Vismodegib的制备方法

Assigned to Suzhou Dongnan Pharmaceutical Research & Development Co Ltd · Expires 2016-10-05 · 10y expired

What this patent protects

本发明提供了Vismodegib的制备方法，即2‑氯‑N‑(4‑氯‑3‑(吡啶‑2‑基)苯基)‑4‑(甲基磺酰基)苯甲酰胺的制备方法。本发明的方法是先制备得中间体2‑(3‑硝基苯基)吡啶，再依次经过氯化反应、还原反应、酰化反应，制备得2‑氯‑N‑(4‑氯‑3‑(吡啶‑2‑基)苯基)‑4‑(甲基磺酰基)苯甲酰胺。本发明涉及的制备方法具有步骤简短、操作简单、反应条件基本无无水要求，对无氧要求较低等特点，能够有效降低生产成本。

USPTO Abstract

本发明提供了Vismodegib的制备方法，即2‑氯‑N‑(4‑氯‑3‑(吡啶‑2‑基)苯基)‑4‑(甲基磺酰基)苯甲酰胺的制备方法。本发明的方法是先制备得中间体2‑(3‑硝基苯基)吡啶，再依次经过氯化反应、还原反应、酰化反应，制备得2‑氯‑N‑(4‑氯‑3‑(吡啶‑2‑基)苯基)‑4‑(甲基磺酰基)苯甲酰胺。本发明涉及的制备方法具有步骤简短、操作简单、反应条件基本无无水要求，对无氧要求较低等特点，能够有效降低生产成本。

Drugs covered by this patent

Patent Metadata

Patent number
CN103910672B
Jurisdiction
CN
Classification
—
Expires
2016-10-05
Drug substance claim
No
Drug product claim
No
Assignee
Suzhou Dongnan Pharmaceutical Research & Development Co Ltd
Source
FDA Orange Book + USPTO grounding via Google Patents

Bibliographic data sourced from FDA Orange Book + USPTO public records. Plain-English summary generated by AI grounded in source text. Patent term extensions (PTR, SPC, pediatric) may shift the effective expiry. Not legal advice.

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