CN Patent

CN103755688A — 一种阿法替尼化合物的制备方法

Assigned to Jiangsu Aosaikang Pharmaceutical Co Ltd · Expires 2014-04-30 · 12y expired

What this patent protects

本发明提供了一种阿法替尼的合成新方法，由二甲氨基巴豆酸盐酸盐，通过酰胺连接试剂活化后或氯化后，与N 4 -(3-氯-4-氟-苯基)-7-((S)-四氢呋喃-3-基氧)喹唑啉-4,6-二胺反应制得。本发明进一步还提供了一种制备二甲氨基巴豆酸盐酸盐的工艺及其中间体。本发明提供的阿法替尼制备方法具备生产成本低、环境污染小、操作简便、适宜工业化生产的优点。

USPTO Abstract

本发明提供了一种阿法替尼的合成新方法，由二甲氨基巴豆酸盐酸盐，通过酰胺连接试剂活化后或氯化后，与N 4 -(3-氯-4-氟-苯基)-7-((S)-四氢呋喃-3-基氧)喹唑啉-4,6-二胺反应制得。本发明进一步还提供了一种制备二甲氨基巴豆酸盐酸盐的工艺及其中间体。本发明提供的阿法替尼制备方法具备生产成本低、环境污染小、操作简便、适宜工业化生产的优点。

Drugs covered by this patent

afatinib-dimaleate (AFATINIB DIMALEATE)

Patent Metadata

Patent number: CN103755688A
Jurisdiction: CN
Classification: —
Expires: 2014-04-30
Drug substance claim: No
Drug product claim: No
Assignee: Jiangsu Aosaikang Pharmaceutical Co Ltd
Source: FDA Orange Book + USPTO grounding via Google Patents

Bibliographic data sourced from FDA Orange Book + USPTO public records. Plain-English summary generated by AI grounded in source text. Patent term extensions (PTR, SPC, pediatric) may shift the effective expiry. Not legal advice.

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