CN Patent

CN103664796A — 5-[2-(5-羧基-嘧啶基)]-1,3-苯二羧酸的合成方法

Assigned to Liaoning Normal University · Expires 2014-03-26 · 12y expired

What this patent protects

本发明的5-[2-(5-羧基-嘧啶基)]-1,3-苯二羧酸的合成方法，先合成化合物A：5-[2-(4,4,5,5-四甲基-1,3,2-硼酸醚)]-1,3-苯甲酸二甲酯，然后在氩气或氮气保护条件下加入催化剂让其与2-氯嘧啶-5-羧酸乙酯在有机溶剂中回流反应，生成最终目标化合物B：5-[2-(5-羧基-嘧啶基)]-1,3-苯二羧酸。本发明的方法与现有技术相比具有合成成本低、产率高、产品纯度高的优点。

USPTO Abstract

本发明的5-[2-(5-羧基-嘧啶基)]-1,3-苯二羧酸的合成方法，先合成化合物A：5-[2-(4,4,5,5-四甲基-1,3,2-硼酸醚)]-1,3-苯甲酸二甲酯，然后在氩气或氮气保护条件下加入催化剂让其与2-氯嘧啶-5-羧酸乙酯在有机溶剂中回流反应，生成最终目标化合物B：5-[2-(5-羧基-嘧啶基)]-1,3-苯二羧酸。本发明的方法与现有技术相比具有合成成本低、产率高、产品纯度高的优点。

Drugs covered by this patent

Kalydeco (IVACAFTOR) · Vertex Pharms Inc

Patent Metadata

Patent number: CN103664796A
Jurisdiction: CN
Classification: —
Expires: 2014-03-26
Drug substance claim: No
Drug product claim: No
Assignee: Liaoning Normal University
Source: FDA Orange Book + USPTO grounding via Google Patents

Bibliographic data sourced from FDA Orange Book + USPTO public records. Plain-English summary generated by AI grounded in source text. Patent term extensions (PTR, SPC, pediatric) may shift the effective expiry. Not legal advice.

Track this patent

Get a daily-checked alert when vulnerability score, expiry, classification, or assignee changes. Email, Slack, or Teams delivery. Pro: 50 watches, Free: 3.