CN Patent

CN103275152B — 一种高纯度非达霉素的制备方法

Assigned to NCPC New Drug Research and Development Co Ltd · Expires 2015-11-18 · 10y expired

What this patent protects

本发明公开了从非达霉素发酵菌丝体中分离纯化非达霉素的方法。该方法是首先将非达霉素发酵液过滤、浸提，浸提液用水稀释后通过大孔树脂脱色、吸附、解析，所得解析液经浓缩、萃取、干燥后得非达霉素粗品；然后将非达霉素粗品用极性有机溶剂溶解，注入聚合物微球柱进行层析分离，得到高纯度的非达霉素精粉。本发明方法有效排除了发酵次级代谢产物的干扰，提高了非达霉素的品质及产品收率。整个工艺简单、易操作；所制备的非达霉素精粉可供药品使用；所制备的非达霉素纯度大于95.0%，全程总收率大于45%。所用溶剂均为常规溶剂，毒性小，适宜于工业化生产。

USPTO Abstract

本发明公开了从非达霉素发酵菌丝体中分离纯化非达霉素的方法。该方法是首先将非达霉素发酵液过滤、浸提，浸提液用水稀释后通过大孔树脂脱色、吸附、解析，所得解析液经浓缩、萃取、干燥后得非达霉素粗品；然后将非达霉素粗品用极性有机溶剂溶解，注入聚合物微球柱进行层析分离，得到高纯度的非达霉素精粉。本发明方法有效排除了发酵次级代谢产物的干扰，提高了非达霉素的品质及产品收率。整个工艺简单、易操作；所制备的非达霉素精粉可供药品使用；所制备的非达霉素纯度大于95.0%，全程总收率大于45%。所用溶剂均为常规溶剂，毒性小，适宜于工业化生产。

Drugs covered by this patent

Patent Metadata

Patent number
CN103275152B
Jurisdiction
CN
Classification
—
Expires
2015-11-18
Drug substance claim
No
Drug product claim
No
Assignee
NCPC New Drug Research and Development Co Ltd
Source
FDA Orange Book + USPTO grounding via Google Patents

Bibliographic data sourced from FDA Orange Book + USPTO public records. Plain-English summary generated by AI grounded in source text. Patent term extensions (PTR, SPC, pediatric) may shift the effective expiry. Not legal advice.

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