CN Patent

CN103254156B — 阿法替尼中间体的制备方法

Assigned to Juancheng People's Hospital · Expires 2015-08-26 · 11y expired

What this patent protects

本发明揭示了一种阿法替尼中间体的制备方法，包括如下步骤：以对羟基苯腈为起始原料，依次通过硝化、醚化、还原、酰胺化、硝化和还原等步骤，制备得到2-腈基-4-[4-(N，N-二甲基氨基)-1-氧代-2-丁烯-1-基]氨基-5-[(S)-(四氢呋喃-3-基)氧基]苯胺(I)。该制备方法工艺稳定、原料易得、成本低廉，所有反应均为经典反应，适合工业化放大要求。

USPTO Abstract

本发明揭示了一种阿法替尼中间体的制备方法，包括如下步骤：以对羟基苯腈为起始原料，依次通过硝化、醚化、还原、酰胺化、硝化和还原等步骤，制备得到2-腈基-4-[4-(N，N-二甲基氨基)-1-氧代-2-丁烯-1-基]氨基-5-[(S)-(四氢呋喃-3-基)氧基]苯胺(I)。该制备方法工艺稳定、原料易得、成本低廉，所有反应均为经典反应，适合工业化放大要求。

Drugs covered by this patent

Patent Metadata

Patent number
CN103254156B
Jurisdiction
CN
Classification
—
Expires
2015-08-26
Drug substance claim
No
Drug product claim
No
Assignee
Juancheng People's Hospital
Source
FDA Orange Book + USPTO grounding via Google Patents

Bibliographic data sourced from FDA Orange Book + USPTO public records. Plain-English summary generated by AI grounded in source text. Patent term extensions (PTR, SPC, pediatric) may shift the effective expiry. Not legal advice.

Track this patent

Get a daily-checked alert when vulnerability score, expiry, classification, or assignee changes. Email, Slack, or Teams delivery. Pro: 50 watches, Free: 3.