CN Patent

CN103044263A — 一种治疗囊性纤维化药物的中间体的制备方法

Assigned to HEFEI YIGONG MEDICINE CO Ltd · Expires 2013-04-17 · 13y expired

What this patent protects

本发明涉及药物合成领域。具体涉及用于治疗囊性纤维化药物Ivacaftor的制备方法。其特征是：以2，4-二叔丁基酚为起始原料，酚羟基用烷氧羰基保护后，再经硝化，还原，与4-氧代-1，4-二氢喹啉-3-甲酰氯缩合得到碳酸2，4-二叔丁基-5-（1，4-二氢-4-氧代喹啉-3-甲酰胺）苯基酯乙基酯，最后于碱性条件下脱除烷氧羰基得到Ivacaftor。本发明方法克服了现有合成方法的诸多缺点，所用原料简单易得、实验操作和后处理方便、收率高、产品质量好，适合规模化生产。

USPTO Abstract

本发明涉及药物合成领域。具体涉及用于治疗囊性纤维化药物Ivacaftor的制备方法。其特征是：以2，4-二叔丁基酚为起始原料，酚羟基用烷氧羰基保护后，再经硝化，还原，与4-氧代-1，4-二氢喹啉-3-甲酰氯缩合得到碳酸2，4-二叔丁基-5-（1，4-二氢-4-氧代喹啉-3-甲酰胺）苯基酯乙基酯，最后于碱性条件下脱除烷氧羰基得到Ivacaftor。本发明方法克服了现有合成方法的诸多缺点，所用原料简单易得、实验操作和后处理方便、收率高、产品质量好，适合规模化生产。

Drugs covered by this patent

Patent Metadata

Patent number
CN103044263A
Jurisdiction
CN
Classification
—
Expires
2013-04-17
Drug substance claim
No
Drug product claim
No
Assignee
HEFEI YIGONG MEDICINE CO Ltd
Source
FDA Orange Book + USPTO grounding via Google Patents

Bibliographic data sourced from FDA Orange Book + USPTO public records. Plain-English summary generated by AI grounded in source text. Patent term extensions (PTR, SPC, pediatric) may shift the effective expiry. Not legal advice.

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