CN Patent

CN102834097B — 纯化的吡咯并喹啉基-吡咯烷-2,5-二酮组合物和用于制备且使用其的方法

Assigned to Arqule Inc · Expires 2015-06-17 · 11y expired

What this patent protects

本发明涉及(-)-反式-3-(5,6-二氢-4H-吡咯并[3,2,1-ij]喹啉-1-基)-4-(1H-吲哚-3-基)吡咯烷-2,5-二酮的1型和2型多晶型物。本发明还涉及具有超过99%手性纯度的(-)-反式-3-(5,6-二氢-4H-吡咯并[3,2,1-ij]喹啉-1-基)-4-(1H-吲哚-3-基)吡咯烷-2,5-二酮化合物，和制备这些化合物的方法。本发明还涉及包含这些(-)-反式-3-(5,6-二氢-4H-吡咯并[3,2,1-ij]喹啉-1-基)-4-(1H-吲哚-3-基)吡咯烷-2,5-二酮化合物的药物组合物。本发明提供了治疗细胞增殖性病症例如癌…

USPTO Abstract

本发明涉及(-)-反式-3-(5,6-二氢-4H-吡咯并[3,2,1-ij]喹啉-1-基)-4-(1H-吲哚-3-基)吡咯烷-2,5-二酮的1型和2型多晶型物。本发明还涉及具有超过99%手性纯度的(-)-反式-3-(5,6-二氢-4H-吡咯并[3,2,1-ij]喹啉-1-基)-4-(1H-吲哚-3-基)吡咯烷-2,5-二酮化合物，和制备这些化合物的方法。本发明还涉及包含这些(-)-反式-3-(5,6-二氢-4H-吡咯并[3,2,1-ij]喹啉-1-基)-4-(1H-吲哚-3-基)吡咯烷-2,5-二酮化合物的药物组合物。本发明提供了治疗细胞增殖性病症例如癌症的方法，其通过给有此需要的受试者施用治疗有效量的包含具有超过99%手性纯度的(-)-反式-3-(5,6-二氢-4H-吡咯并[3,2,1-ij]喹啉-1-基)-4-(1H-吲哚-3-基)吡咯烷-2，5-二酮的组合物、或(-)-反式-3-(5,6-二氢-4H-吡咯并[3,2,1-ij]喹啉-1-基)-4-(1H-吲哚-3-基)吡咯烷-2,5-二酮的1型和2型多晶型物实施。

Drugs covered by this patent

Patent Metadata

Patent number
CN102834097B
Jurisdiction
CN
Classification
—
Expires
2015-06-17
Drug substance claim
No
Drug product claim
No
Assignee
Arqule Inc
Source
FDA Orange Book + USPTO grounding via Google Patents

Bibliographic data sourced from FDA Orange Book + USPTO public records. Plain-English summary generated by AI grounded in source text. Patent term extensions (PTR, SPC, pediatric) may shift the effective expiry. Not legal advice.

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