CN Patent

CN102731458B — 双异戊烯基香豆素及其制备方法和应用

Assigned to South China Sea Institute of Oceanology of CAS · Expires 2014-03-26 · 12y expired

What this patent protects

本发明公开了一种双异戊烯基香豆素及其制备方法和应用。本发明从大管（Micromelum falcatum）中分离得到一个新的化合物——如式（I）所示的双异戊烯基香豆素，该化合物对卤虫的LD 50 值为25.5μg/mL，对藤壶幼虫的抗附着活性浓度IC 50 是6.77μg/mL；对肺癌细胞HvEvc的平均半数抑制率IC 50 为76.4μg/mL，因此可将该化合物用于制备抗卤虫药物、抗污损生物幼虫附着药物和抗肿瘤药物或作为前导化合物，具有广阔的应用前景。

USPTO Abstract

本发明公开了一种双异戊烯基香豆素及其制备方法和应用。本发明从大管（Micromelum falcatum）中分离得到一个新的化合物——如式（I）所示的双异戊烯基香豆素，该化合物对卤虫的LD 50 值为25.5μg/mL，对藤壶幼虫的抗附着活性浓度IC 50 是6.77μg/mL；对肺癌细胞HvEvc的平均半数抑制率IC 50 为76.4μg/mL，因此可将该化合物用于制备抗卤虫药物、抗污损生物幼虫附着药物和抗肿瘤药物或作为前导化合物，具有广阔的应用前景。

Drugs covered by this patent

Patent Metadata

Patent number: CN102731458B
Jurisdiction: CN
Classification: —
Expires: 2014-03-26
Drug substance claim: No
Drug product claim: No
Assignee: South China Sea Institute of Oceanology of CAS
Source: FDA Orange Book + USPTO grounding via Google Patents

Bibliographic data sourced from FDA Orange Book + USPTO public records. Plain-English summary generated by AI grounded in source text. Patent term extensions (PTR, SPC, pediatric) may shift the effective expiry. Not legal advice.

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