CN Patent

CN1015542B — (R)-α-乙基-2-氧代-1-吡咯烷乙酰胺的制备方法

Assigned to UCB SA · Expires 1992-02-19 · 34y expired

What this patent protects

本发明涉及(R)-α-乙基-2-氧化-1-吡咯烷乙酰胺的制备方法。该化合物可用(R)-α-乙基-2-氧代-1-吡咯烷乙酸和卤代甲酸烷基酯反应，再与氨反应制得。或将式(A)的(R)-2-氨基-丁酰胺环化制得。式中X为ZOOC-时，Y是-CH 2 -，X为HalCH 2 -时，Y是-CO-。Z为C 1-4 烷基Hal是卤原子。该右旋对映体较之相应的外消旋体记忆效能高，毒性低。 X-CH 2 CH 2 -Y-NHCH(C 2 H 5 )CONH 2 ----(A)

USPTO Abstract

本发明涉及(R)-α-乙基-2-氧化-1-吡咯烷乙酰胺的制备方法。该化合物可用(R)-α-乙基-2-氧代-1-吡咯烷乙酸和卤代甲酸烷基酯反应，再与氨反应制得。或将式(A)的(R)-2-氨基-丁酰胺环化制得。式中X为ZOOC-时，Y是-CH 2 -，X为HalCH 2 -时，Y是-CO-。Z为C 1-4 烷基Hal是卤原子。该右旋对映体较之相应的外消旋体记忆效能高，毒性低。 X-CH 2 CH 2 -Y-NHCH(C 2 H 5 )CONH 2 ----(A)

Drugs covered by this patent

Patent Metadata

Patent number
CN1015542B
Jurisdiction
CN
Classification
—
Expires
1992-02-19
Drug substance claim
No
Drug product claim
No
Assignee
UCB SA
Source
FDA Orange Book + USPTO grounding via Google Patents

Bibliographic data sourced from FDA Orange Book + USPTO public records. Plain-English summary generated by AI grounded in source text. Patent term extensions (PTR, SPC, pediatric) may shift the effective expiry. Not legal advice.

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