CN Patent

CN100508969C — 紫杉烷环糊精包合物纳米粒及其制备方法

Assigned to Shanghai Allist Medicine Polytron Technologies Inc · Expires 2009-07-08 · 17y expired

What this patent protects

本发明公开了一种紫杉烷，尤其是紫杉醇环糊精包合物纳米粒及其药物制剂。利用羟丙基-β-环糊精为载体，聚维酮为稳定剂，制备得到紫杉醇包合物纳米粒，粒径为40-200nm，该环糊精包合物纳米粒使紫杉醇的溶解度增加了100-500倍。动物实验显示，与市售紫杉醇相比，耐受剂量提高了2.67倍，抑瘤效果明显增强。本发明采用常规辅料，工艺条件简单，适合工业规模生产，产品质量稳定，可直接或二次加工制备成注射或口服制剂，从而对抗癌药物紫杉烷用于临床提供了一种新的有效途径。

USPTO Abstract

本发明公开了一种紫杉烷，尤其是紫杉醇环糊精包合物纳米粒及其药物制剂。利用羟丙基-β-环糊精为载体，聚维酮为稳定剂，制备得到紫杉醇包合物纳米粒，粒径为40-200nm，该环糊精包合物纳米粒使紫杉醇的溶解度增加了100-500倍。动物实验显示，与市售紫杉醇相比，耐受剂量提高了2.67倍，抑瘤效果明显增强。本发明采用常规辅料，工艺条件简单，适合工业规模生产，产品质量稳定，可直接或二次加工制备成注射或口服制剂，从而对抗癌药物紫杉烷用于临床提供了一种新的有效途径。

Drugs covered by this patent

Patent Metadata

Patent number
CN100508969C
Jurisdiction
CN
Classification
—
Expires
2009-07-08
Drug substance claim
No
Drug product claim
No
Assignee
Shanghai Allist Medicine Polytron Technologies Inc
Source
FDA Orange Book + USPTO grounding via Google Patents

Bibliographic data sourced from FDA Orange Book + USPTO public records. Plain-English summary generated by AI grounded in source text. Patent term extensions (PTR, SPC, pediatric) may shift the effective expiry. Not legal advice.

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