CN Patent

CN100457776C — 丙型肝炎病毒ns5b聚合酶抑制剂结合袋

Assigned to Boehringer Ingelheim International GmbH · Expires 2009-02-04 · 17y expired

What this patent protects

HCV聚合酶，当与某些抑制剂复合时，会采用取代手指环区而暴露结合袋的构象，其中所述手指环区由氨基酸残基18至35定义，结合袋通常由氨基酸残基392，393，395，396，399，424，425，428，429，492，493，494，495，496，500和503定义。这种新的暴露型结合袋为寻找能结合HCVNS5B，并调节或优选抑制HCV NS5B聚合酶活性的其它化学实体定义了一种新的靶标。

USPTO Abstract

HCV聚合酶，当与某些抑制剂复合时，会采用取代手指环区而暴露结合袋的构象，其中所述手指环区由氨基酸残基18至35定义，结合袋通常由氨基酸残基392，393，395，396，399，424，425，428，429，492，493，494，495，496，500和503定义。这种新的暴露型结合袋为寻找能结合HCVNS5B，并调节或优选抑制HCV NS5B聚合酶活性的其它化学实体定义了一种新的靶标。

Drugs covered by this patent

Patent Metadata

Patent number: CN100457776C
Jurisdiction: CN
Classification: —
Expires: 2009-02-04
Drug substance claim: No
Drug product claim: No
Assignee: Boehringer Ingelheim International GmbH
Source: FDA Orange Book + USPTO grounding via Google Patents

Bibliographic data sourced from FDA Orange Book + USPTO public records. Plain-English summary generated by AI grounded in source text. Patent term extensions (PTR, SPC, pediatric) may shift the effective expiry. Not legal advice.

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