CN Patent

CN100355732C — 2－氯－5－氟－烟酸酯及酸的制备方法

Assigned to Wuxi Apptec Co Ltd · Expires 2007-12-19 · 18y expired

What this patent protects

本发明涉及一种新的2-氯-5-氟-烟酸酯及酸制备方法。解决了即知方法的收率过低，路线长及使用异臭的硫醇的缺陷。技术解决方案是通过2，6-二氯-5-氟-烟酸及相关羧酸酯直接选择性脱掉6位上的氯原子，以及通过2-氯-5-氟-烟酸酯在碱性物质存在下水解为2-氯-5-氟-烟酸。化学反应式如下：主要用于制备2-氯-5-氟-烟酸酯及2-氯-5-氟-烟酸药物中间体。

USPTO Abstract

本发明涉及一种新的2-氯-5-氟-烟酸酯及酸制备方法。解决了即知方法的收率过低，路线长及使用异臭的硫醇的缺陷。技术解决方案是通过2，6-二氯-5-氟-烟酸及相关羧酸酯直接选择性脱掉6位上的氯原子，以及通过2-氯-5-氟-烟酸酯在碱性物质存在下水解为2-氯-5-氟-烟酸。化学反应式如下：主要用于制备2-氯-5-氟-烟酸酯及2-氯-5-氟-烟酸药物中间体。

Drugs covered by this patent

Patent Metadata

Patent number
CN100355732C
Jurisdiction
CN
Classification
—
Expires
2007-12-19
Drug substance claim
No
Drug product claim
No
Assignee
Wuxi Apptec Co Ltd
Source
FDA Orange Book + USPTO grounding via Google Patents

Bibliographic data sourced from FDA Orange Book + USPTO public records. Plain-English summary generated by AI grounded in source text. Patent term extensions (PTR, SPC, pediatric) may shift the effective expiry. Not legal advice.

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