CA3255619A1 — Cyclic lipids and lipid nanoparticles (lnp) for the delivery of nucleic acids or peptides for use in vaccinating against infectious agents

USPTO Abstract

The present invention relates to compounds of formula (CX-II) or a pharmaceutically acceptable salt thereof, wherein Z is selected from the group consisting of a bond, (I), (II) and (III); each Y is independently selected from the group consisting of (TV), (V) and (VI); R¹ is-(CH₂) ₁₋₆N(Rᵃ)20r (CH₂)₁₋₆ OH; R is optionally substituted C₅-C₃₆ alkyl or optionally substituted C₅-C₃₆ alkenyl, wherein 2 methylene units of R are replaced with -O- to form an acetal within R and wherein 1-6 methylene units of R are optionally replaced with a group each independently selected from cyclopropylene, -O-, -OC(O)-, and -C(O)O-; R is optionally substituted C1-C36 alkyl or optionally substituted C₁-C₃₆ alkenyl, wherein 1-6 methylene units of R are optionally replaced with a group each independently selected from cyclopropylene, -O-, -OC(O)-, and -C(O)O-; for use as cyclic lipids in lipid nanoparticles (LNPs) for the delivery of nucleic acid sequences, polypeptides or peptides for use in vaccinating against infectious agents.