CA3218585A1 — Composition for treating autoimmune, alloimmune, inflammatory, and mitochondrial conditions, and uses thereof

USPTO Abstract

Provided herein are compositions and methods for treating autoimmune, alloimmune, inflammatory, and mitochondrial conditions. Specifically, the disclosure provides a method of treating an alloimmune, autoimmune, inflammatory, or mitochondrial condition in a subject, the method comprising: administering a calcineurin inhibitor and a cytochrome p450 inhibitor, wherein calcineurin inhibitor comprising cyclosporine, tacrolimus, pimecrolimus, or analogs or derivatives thereof. Further disclosed are cytochrome p450 inhibitors that can be used for the method.