CA3215414A1 — Therapeutic agent for gait disturbance

USPTO Abstract

The present invention relates to a therapeutic agent for a gait disturbance of a patient associated with an ischemic disease, the therapeutic agent containing, as an active ingredient, a heterocyclic derivative represented by general formula (1) or a pharmaceutically acceptable salt thereof. In formula (1), R1 and R2, which may be the same or different, each represent aryl that may be substituted; R3 and R4, which may be the same or different, each represent a hydrogen atom or alkyl; R5 represents a hydrogen atom, alkyl or a halogen atom; Y represents N or N?O; A represents NR6 and R6 represents a hydrogen atom, alkyl or the like; D represents alkylene or alkenylene that may be substituted with hydroxy; E represents phenylene or a single bond; G represents O, S, or the like; and Q represents carboxy, alkoxycarbonyl, or the like.