CA Patent

CA3092089A1 — Methods and compositions for treating bile duct paucity-associated conditions

Assigned to Dicerna Pharmaceuticals Inc · Expires 2019-09-06 · 7y expired

What this patent protects

This disclosure relates to oligonucleotides, compositions and methods useful for reducing CTNNB1 expression, particularly in hepatocytes, for the treatment of bile duct paucity-associated conditions. Disclosed oligonucleotides for the reduction of CTNNB1 expression may be double-…

USPTO Abstract

This disclosure relates to oligonucleotides, compositions and methods useful for reducing CTNNB1 expression, particularly in hepatocytes, for the treatment of bile duct paucity-associated conditions. Disclosed oligonucleotides for the reduction of CTNNB1 expression may be double- stranded or single- stranded, and may be modified for improved characteristics such as stronger resistance to nucleases and lower immunogenicity. Disclosed oligonucleotides for the reduction of CTNNB1 expression may also include targeting ligands to target a particular cell or organ, such as the hepatocytes of the liver.

Drugs covered by this patent

Patent Metadata

Patent number
CA3092089A1
Jurisdiction
CA
Classification
—
Expires
2019-09-06
Drug substance claim
No
Drug product claim
No
Assignee
Dicerna Pharmaceuticals Inc
Source
FDA Orange Book + USPTO grounding via Google Patents

Bibliographic data sourced from FDA Orange Book + USPTO public records. Plain-English summary generated by AI grounded in source text. Patent term extensions (PTR, SPC, pediatric) may shift the effective expiry. Not legal advice.

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