CA3086751A1 — Compositions and methods of treating cancer with glycomimetic peptides

USPTO Abstract

CA 03086751 2020-06-23 (12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property 1 11111 1111111 11 111111 111 11111 11111111 1 1 111 1111 1111 1111 1111 11111 111 11111111111 111 1111 Organization International Bureau (10) International Publication Number (43) International Publication Date WO 2019/136185 Al 11 July 2019 (11.07.2019) WIPO I PCT (51) International Patent Classification: (74) Agent: FULLER, Rodney J.; Booth Udall Fuller, PLC, A61K 31/337 (2006.01) A 61K 31/496 (2006.01) 1255 W. Rio SMado Parkway, Suite 215, Tempe, Arizona A61K 31/475 (2006.01) A 61K 31/704 (2006.01) 85281 (US). (21) International Application Number: (81) Designated States (unless otherwise indicated, for every PCT/U52019/012228 kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, (22) International Filing Date: CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, 03 January 2019 (03.01.2019) DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, (25) Filing Language: English HR, HU, ED, EL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, (26) Publication Language: English MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, (30) Priority Data: OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, 62/614,956 08 January 2018 (08.01.2018) US SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, 62/699,345 1'7 July 2018 (17.07.2018) US TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (71) Applicant: SUSAVION BIOSCIENCES, INC. [US/US]; (84) Designated States (unless otherwise indicated, for every 1615 W. University Drive, Suite 132, Tempe, Arizona kind of regional protection available): ARIPO (BW, GH, 85281 (US). GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, (72) Inventors: EGGINK, Laura L.; 2538 N. 87th Way, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, Scottsdale, Arizona 8525'7 (US). HOOBER, J. Kenneth; EE, ES, FI, FR, GB, GR, HR, HU, EE, IS, IT, LT, LU, LV, 15849 S. 13th Way, Phoenix, Arizona 85048 (US). MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, (54) Title: COMPOSITIONS AND METHODS OF TREATING CANCER WITH GLYCOMIMETIC PEPTIDES NE12-VQATQSNQHTPRGGGS, !v. NH2-VQATQSNQHTPRGGGS-te NFI2-VQATQSNQHTPRGGGS =$.* \*.t. NH2¨VQATQSNQHTPRGGGS-N" ............................... svL4 4!C kin FIG . lA oc (57) Abstract: The present disclosure relates to pharmaceutical compositions comprising a peptide or multivalent polypeptide, and re) an anti-cancer agent. In some embodiments, the anti-cancer agent is conjugated to the peptide or multivalent polypeptide. The present ***---- disclosure also relates to a method of treating cancer or reducing cancer cell proliferation using the peptide or multivalent polypeptide. In some aspects, the peptide or multivalent polypeptide enhances the efficacy of the anti-cancer agent, the targeting of the anti-cancer 0 agent to the cancer cells, or both. [Continued on next page] CA 03086751 2020-06-23 WO 2019/136185 Al I11111 NMI II lIllIl 11111 11111 011MI I II 111 11111 0ll 11111 11111 11111 lH 11111111111 0l 1111 TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Published: ¨ with international search report (Art. 21(3)) ¨ before the expiration of the time limit for amending the claims and to be republished in the event of receipt of amendments (Rule 48.2(h)) ¨ with sequence listing part of description (Rule 5.2(a))