CA2861339C — Metalloenzyme inhibitor compounds

USPTO Abstract

The disclosure provides metalloenzyme inhibitor compounds and the use thereof. The compounds are of Formula (I), wherein MBG is tetrazolyl; R1 is fluoro; R2 is fluoro; R3 is haloalkoxyalkyl; R4 is 2,4-difluorophenyl; R5 is hydrogen or -P(O)(OH)2; R6 is hydrogen or halo; and n is 1. The compound can be used for inhibiting metalloenzyme activity. The compounds can be used to inhibit metalloenzyme activity, to modulate metalloenzyme activity in a subject, to treat a subject subject suffering from or susceptible to a metalloenzyme-related disorder or disease, to treat treating a subject suffering from or susceptible to a metalloenzyme-related disorder or disease, wherein the subject has been identified as in need of treatment for a metalloenzyme-related disorder or disease, and to treat a subject suffering from or susceptible to a metalloenzyme-mediated disorder or disease. The disclosure also provides a composition comprising the compound and a pharmaceutically acceptable carrier. (see formula I)