CA2856037C — Modulators of atp-binding cassette transporters

USPTO Abstract

A compound of formula (I): (see formula I) or a pharmaceutically acceptable salt thereof, a pharmaceutical composition comprising a compound according to formula (I) and a pharmaceutically acceptable carrier, a kit for use in measuring the activity of an ABC transporter or a fragment thereof in a biological sample in vitro or in vivo, comprising a composition comprising the compound of formula (I) and instructions for a) contacting the composition with the biological sample and b) measuring activity of said ABC transporter or a fragment thereof, and use of an effective amount of the compound of formula (I) or the pharmaceutically acceptable salt thereof for treating or lessening the severity of a disease in a patient need thereof.