CA2829825C — Low volume colon cleansing solutions comprising ascorbate and polyethylene glycol

USPTO Abstract

The invention provides a colon cleansing solution comprising: a) 300 to 2000 mmol per litre ascorbate anion provided by ascorbic acid, one or more salts of ascorbic acid, or a mixture thereof; and b) 10 to 200 g per litre polyethylene glycol. The invention also provides methods and kits associated with, or making use of the solutions. The invention also provides a method of cleansing the colon of a subject comprising: - administering to the subject an effective amount of a first cleansing solution; and then after a time interval -administering to the subject an effective amount of a second cleansing solution, where in the two cleansing solutions are as described in the specification. Solutions of the invention are surprisingly effective colon cleansing solutions as measured by stool output, providing satisfactory clearance of stools from the colon with ingestion of a smaller total volume of solution than with standard 2 or 4 litre solutions of the prior art. Many subjects find the ingestion of a large volume unpleasant or difficult and poor patient compliance is a problem.