CA2767899A1 — Nitrogen-containing spiro-ring compound and medicinal use of same

USPTO Abstract

Disclosed are a compound represented by general formula [I], a pharmaceutically acceptable salt thereof or a solvate of the same, and medicinal use thereof for treating rejection in organ transplantation, graft-versus-host reaction after organ transplantation, autoimmune diseases, allergic diseases and chronic myeloproliferative diseases by using these compounds as the active ingredient. In general formula [I], Ra's are the same or different and represent (1) a C1-6 alkyl group, etc.; n1 represents an integer of 0 to 4; Rb's are the same or different and represent (1) a C1-6 alkyl group, etc.; n2 represents an integer of 0 to 4; m1 represents an integer of 0 to 3; m2 represents an integer of 1 to 4; Xa=Xb represents (1) CH=CH, etc.; X represents (1) a nitrogen atom, etc.; and Rc represents (1) a hydrogen atom, etc.