CA2760061C — Diamino heterocyclic carboxamide compound

USPTO Abstract

Disclosed are a compound represented by formula (I) or a sale thereof; a kinase inhibitor for EML4-ALK fusion protein containing the compound; and use of the compound for the treatment of cancers. (In formula (I), -X- represents a group represented by formula (II) or formula (III); A represents ¨H, a halogen atom, a lower alkyl group, a cycloalkyl group or a lower alkenyl group; R1 represents a substituted phyenyl group, a (substituted) heterocyclic group or a (substituted) bicyclic fused ring; R2 represents a (substituted) cycloalkyl group, a (substituted) non-aromatic heterocyclic group, a (substituted) phenyl group, a (substituted) pyridyl group or a (substituted) lower alkyl group; and R3 represents ¨H or a lower alkyl group; or alternatively R2 and R3 may combine together to form a cyclic amino group.