CA2759063C — 4-[(3-chloro-4-fluorophenyl)amino]-6-{[4-(n,n-dimethylamino)-1-oxo-2-buten-1-yl]amino}-7-((s)-tetrahydrofuran-3-yloxy)-quinazoline dimaleate and the use thereof

USPTO Abstract

The invention provides the compound 4-[(3-chloro-4- fluorophenyl)amino]-6-{[4-(N, N-dimethylamino)-1-oxo-2-buten-1-yl]amino}-7- ((S)- tetrahydrofuran-3-yloxy)-quinazoline dimaleate. The compound may be used for treatment of a benign or malignant tumour, for preventing or treating a disease of the respiratory tract and lungs or for treating a disease of the gastro-intestinal tract, or the bile duct and gall bladder. The invention also provides a process for preparing a dimaleate of 4-[(3-chloro-4-fluorophenyl)amino]-6-{[4-(N, N-dimethylamino)-1- oxo-2- buten-1-yl]amino}-7-((S)-tetrahydrofuran-3-yloxy)-quinazoline, comprising: converting 4-[(3-chloro-4-fluorophenyl)amino]-6-{[4-(N, N-dimethylamino)-1-oxo-2-buten-1- yl]amino}-7-((S)-tetrahydrofuran-3-yloxy)-quinazoline into the dimaleate by reacting with maleic acid in a suitable solvent, with heating.