CA2732984A1 — Process for production of bicyclo[2.2.2]octylamine derivative

USPTO Abstract

Disclosed is a production process which can synthesize a bicyclo[2.2.2]octylamine derivative (which can be used as an intermediate for the production of a pharmaceutical agent) efficiently under mild conditions in a large quantity. The bicyclo[2.2.2]octylamine derivative can be produced by cyclizing a compound represented by general formula (1) [wherein R1 represents an alkyl group having 1 to 6 carbon atoms which may have a substituent, an arylmethyl group which may have a substituent, or an arylethyl group which may have a substituent] with a compound represented by general formula (2): R2-NH2 [wherein R2 represents an alkyl group having 1 to 6 carbon atoms which may have a substituent, an aralkyl group which may have a substituent, a hydroxy group, an alkyloxy group having 1 to 6 carbon atoms which may have a substituent, or an aralkyloxy group which may have a substituent] and reducing the resulting product.