CA2675755A1 — Pyridine and pyridazine derivatives as kinase inhibitors

USPTO Abstract

There are provided compounds of formula II: (see formula II) or a salt thereof; or a hydrate, solvate, or polymorph thereof; wherein R1;R2; R3 and R5 can each represent various possible entities. Such compounds are effective for treating various diseases. For example, the disease can be mediated by the c-met or ron kinases. For example, the disease can be cancer or a proliferation disease. For example, the disease can be lung, colon, breast, prostate, liver, pancreas, brain, kidney, ovaries, stomach, skin, and bone cancers, gastric, breast, pancreatic cancer, glioma, and hepatocellular carcinoma, papillary renal carcinoma, head and neck squamous cell carcinoma.