CA2650422A1 — Process for producing polymer micelles encapsulating low molecular weight drugs

USPTO Abstract

A method of encapsulating a low molecular chemical in a polymer micelle which comprises the following steps: (a) dissolving or dispersing the above-described chemical, which has been electrically charged, in an aqueous medium; (b) preparing an aqueous medium containing the polymer micelle as described above which comprises an area having a hydrophobic side chain and a side chain charged oppositely to the low molecular chemical distributed at random and being hydrophobic as a whole and a hydrophilic area; (c) mixing the aqueous medium having the low molecular chemical dissolved or dispersed therein with the aqueous medium containing the polymer micelle; and (d) adjusting the aqueous medium mixture thus obtained to a pH value at which the encapsulation of the low molecular chemical is stabilized.