CA2636274C — Salts of potassium atp channel openers and uses thereof

USPTO Abstract

Provided are immediate or prolonged administration of certain salts of KATP channel openers such as diazoxide to a subject to achieve novel pharmacodynamic, phatinacokinetic, therapeutic, physiological, metabolic and compositional outcomes in the treatment of diseases or conditions involving KATP channels. The salt comprising an anion and a cation wherein the anion is selected from the group consisting of Formula I, II, III and IV: (see Formula I) (see Formula II) (see Formula III) (see Formula IV) Also provided are pharmaceutical formulations, methods of administration and dosing of the salts that achieve these outcomes and reduce the incidence of adverse effects in treated individuals. Further provided are method of co-administering the salts with other drugs to treat diseases of humans and animals.