CA2624772C — Compounds and kits for the detection and the quantification of cell apoptosis

USPTO Abstract

The present invention relates a compound of formula (I) wherein: - R1 represents a linear alkyl group of 4 to 20 carbon atoms; - Y represents a linear alkyl group of 1 to 5 carbon atoms or a group of formula -R-O-R'-, -R-CO-R'- or -R-CO-NH-R'-, in which R represents a linear alkyl group of 1 to 3 carbon atoms, R' represents a linear alkylene group of 0-3 carbon atoms, Y being linked to the bicycle in position 6 or 7; - Z represents a linear alkyl chain of 3 or 4 carbon atoms; - A represents an oxygen atom, a sulphur atom, or a -NH group, or an amminoalkyl group -NR'' in which R" represents an alkyl group of 1 to 20 carbon atoms; - Ar represents an aromatic cycle or polycycle consisting of 6 to 14 carbon atoms, or an aromatic heterocycle, said heterocycle containing 4, 5 or 6 carbon atoms and at least one heteroatom selected in the group consisting of N, S, and O, or a condensed aromatic heterobicycle, said heterobicycle consisting of 6 to 9 carbon atoms and at least one heteroatom selected in the group consisting of N, S, and O ; - R2 and R3, which are identical or different, each representing a hydrogen atom or an alkyl group of 1 to 4 carbon atoms, R2 and R3 optionally forming a 5- to 7-membered ring with the nitrogen atom; - R4, R5 and R6, identical or different, represent an hydrogen, a linear alkyl group or a linear oxyalkyl group of 1 to 4 carbon atoms.