CA2606282C — Polycyclic carbamoylpyridone derivatives having hiv integrase inhibitory activity

USPTO Abstract

Novel compounds of formula (I) shown below are provided, having anti-HIV activity, particularly HIV integrase inhibitory activity, as well as processes for their preparation and intermediates used therein, for potential use as anti-HIV drugs. (see formula I) (wherein Z1 is NR4; R1 is hydrogen or lower alkyl; X is a single bond, a hetero atom group selected from O, S, SO, SO2 and NH, or lower alkylene or lower alkenylene in which the hetero atom group may intervene; R2 is optionally substituted aryl; R3 is hydrogen, a halogen, hydroxy, optionally substituted lower alkyl etc; and R4 and Z2 part taken together forms a ring, to form a polycyclic compound, including e.g., a tricyclic or tetracyclic compound.)