CA2564542A1 — Combination formulations of anthracycline agents and cytidine analogs

USPTO Abstract

Compositions which comprise an anthracycline agent, and a cytidine analog ar e encapsulated in liposomal carriers. The preferred anthracycline agent is selected from the group of daunorubicin, doxorubicin, and idarubicin, while the preferred cytidine analog is selected from the group of cytarabine, gemcitabine, or 5-azacytidine. The combination of the anthracycline agent an d cytidine analog encapsulated in said liposomal carriers are useful in achieving a drug retention and a sustained drug release for each therapeutic agent.