CA2560613C — Oral pharmaceutical compositions of lipase-containing products, in particular of pancreatin, containing surfactants

USPTO Abstract

The invention relates to novel pharmaceutical compositions of lipase-containing products for oral administration, in particular pancreatin and pancreatin-containing prod~ucts, or of enzyme products which contain at least one lipase of non-animal, especially microbial origin. These pharmaceutical compositions improve the lipolytic activity and in particular result in stabilisation of the lipase in the acidic pH range. These novel oral pharmaceutical compositions are characterized in that they contain a system which comprises at least one surfactant and one co-surfactant and optionally a lipophilic phase, and that they are self-emulsifiable on contact with a hydrophilic and a lipophilic phase. These novel pharmaceutical compositions are well suited for the treatment and/or prophylaxis of maldigestion, in particular maldigestion based on chronic exocrine pancreatic insufficiency, in mammals and humans.