CA2557320A1 — Fused heterocyclic derivatives for prevention or treatment of hyperglycemia

USPTO Abstract

A nitrogenous fused-ring derivative represented by the following general formula (I), a pharmacologically acceptable salt thereof, or a prodrug of either. They have human SGLT inhibitory activity and are useful as a preventive or therapeutic agent for diseases attributable to hyperglycemia, such as diabetes, postprandial hyperglycemia, impaired glucose tolerance, complications of diabetes, and obesity. [In the formula (I), one of R1 and R4 represents a group represented by the following general formula (S) (wherein R5 and R6 each represents H, OH, halogeno, etc.; Q represents alkylene, etc.; and ring A represents aryl, etc.) and the other represents H, OH, amino, etc.; R2 and R3 each represents H, OH, amino, halogeno, optionally substituted alkyl, etc.; A1 represents O, S, etc.; A2 represents CH or N; and G represents a group represented by the following general formula (G-1) (wherein E1 is H, F, or OH and E2 represents H, F, methyl, etc.) or the group represented by the following general formula (G-2).]