CA2557269A1 — Fused heterocycle derivative, medicinal composition containing the same, and medicinal use thereof

USPTO Abstract

A fused heterocycle derivative represented by the following general formula (I), a pharmacologically acceptable salt thereof, or a prodrug of either [in the formula, R1 to R4 each is hydrogen, OH, amino, etc.;R5 and R6 each is hydrogen, OH, halogeno, optionally substituted alkyl, etc.; Q is alkylene, alkenylene, etc.; ring A is aryl or heteroaryl; the ring (R1) shown below is any of the rings (R2) shown below; and G is a group represented by the following general formula (G-1) or (G-2) (wherein E1 is hydrogen, fluorine, or OH; and E2 is hydrogen, fluorine, methyl, etc.)]. They have human SGLT inhibitory activity and are useful as a preventive or therapeutic agent for diseases attributable to hyperglycemia, such as diabetes, postprandial hyperglycemia, impaired glucose tolerance, complications of diabetes, and obesity.