CA2528776A1 — Antifungal formulations

USPTO Abstract

A topical composition and the method using the composition, which contains a n antifungal agent and a low potency anti-inflammatory steroid which is safe a nd effective such as desonide or its derivative. The low potency steroid agent does not cause side effects such as skin atrophy, striae and hypopigmentatio n. In a representative example, the low potency anti~inflammatory steroid has t he following structure: wherein RI, R2, R3, and R4 taken independently can be H , C 1-C 10 alkyl, C 1~C 10 alkenyl, C3 -C 10 cycloalkyl, and phenyl groups; RI and R2 taken together can be C3-C10 cycloalkyl; and R3, and R4 taken independently can be H, C 1-C 10 alkyl, C 1-C 10 alkenyl, C3 -C 10 cycloalky l, phenyl, C7-C 10 phenylalkyl, carboxylate, sulfonyl, phosphoryl, and phosphon yl groups. The composition can be formulated in a dosage form such as a cream, ointment, gel, lotion, foam, powder, aerosol, spray, shampoo, or liquid solution. The composition can be used to treat a fungal disease such as tine a pedis, tinea capitis, tinea corporis, tinea versicolor, tinea cruris, and candidiasis as well as intertriginous dermatitis complicated by candidiasis.