CA2459886A1 — 1-glyoxlylamide indolizines for treating cancer

USPTO Abstract

Disclosed is a compound represented by Structural Fonnula (I): Ring A is substituted or unsubstituted and optionally fused to an aryl group. Z1 and Z 2 are independently =0, =S, =N-OR12 or =NR12; R1 and R2 are independently -H, an aliphatic group, a substituted aliphatic group, an unsubstituted non-aromati c heterocylic group, a substituted non-aromatic heterocylic group, an aryl gro up or a substituted aryl group, provided that R1 and R2 are not both -H. Alternatively, -NR1R2, taken together, is a substituted or unsubstituted non - aromatic nitrogen-containing heterocyclic group or a substituted or unsubstituted nitrogen-containing heteroaryl group. R3 is a substituted or unsubstituted aryl group or a substituted or unsubstituted aliphatic group. X is a covalent bond, -C(R4R5)-, -N(R4)-, -0-, -S-, -S(O)-, -S(0)2-, -C(=O)-, - C(=0)-N(R4)-, or N(R4)-C(=O)-. R4 and R5 are independently -H or a substitut ed or unsubstituted aliphatic group. R12 is -H or a substituted or unsubstitute d alkyl group.