CA2458131A1 — Jnk activation inhibitor

USPTO Abstract

Inhibitors against c-Jun N-terminal kinase, containing compounds represented by the general formula (A) or salts or prodrugs thereof: (A) wherein Ara and Arb are each an optionally substituted aromatic group, or Ara and Arb togeth er with the carbon atom adjacent thereto may form a fused ring; Ba is an optionally substituted nitrogenous heterocycle; Xa and Ya are each independently (1) a free valency, (2) oxygen, (3) S(O)p (wherein p is an integer of 0 to 2), (4) NRd (wherein Rd is hydrogen or lower alkyl), or (5) a bivalent linear lower hydrocarbon group which may be substituted and/or interrupted by one to three heteroatoms; Aa is an optionally substituted fiv e- membered ring; Ra and Rb are each independently (1) hydrogen, (2) halogeno, (3) optionally substituted hydrocarbyl, (4) acyl, or (5) optionally substituted hydroxyl; and Rc is (1) hydrogen, (2) hydroxyl which may be substituted with lower alkyl, or (3) carboxyl.