CA2451161A1 — Method for high through put screening using a small scale mill or microfluidics
Assigned to Perrigo Pharma International DAC · Expires 2003-01-03 · 23y expired
What this patent protects
The present invention is directed to a high throughput screening (HTS) metho d, comprising reducing the particle size of a poorly soluble candidate compound to about 1 micron or less using a small scale mill or microfluidics. The product produced from this process is a dispersion…
USPTO Abstract
The present invention is directed to a high throughput screening (HTS) metho d, comprising reducing the particle size of a poorly soluble candidate compound to about 1 micron or less using a small scale mill or microfluidics. The product produced from this process is a dispersion of a nanoparticulate candidate compound having one or more surface stabilizers adsorbed onto the surface of teh compound. The reduction in particle size results in an increa se in the solubility and/or dispersibility of the compound, thus increasing the effectiveness of HTS conducted in conjunction with the particle size reducti on process. The particle size reduction process can be conducted before HTS to make screening compounds soluble and/or dispersible, or after HTS to validat e an insoluble or poorly compound determined to be active after screening.</SD OAB>
Drugs covered by this patent
Bibliographic data sourced from FDA Orange Book + USPTO public records. Plain-English summary generated by AI grounded in source text. Patent term extensions (PTR, SPC, pediatric) may shift the effective expiry. Not legal advice.
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