CA2438593C — Glucopyranosyloxypyrazole derivatives and medicinal use thereof

USPTO Abstract

The present invention provides glucopyranosyloxypyrazole derivatives represented by the general formula: (see formula I) wherein one of Q and T represents a group represented by the general formula: (see formula II) while the other represents a lower alkyl group or a halo (lower alkyl) group; R1 represents a hydrogen atom, an optionally substituted lower alkyl group, a lower alkenyl group, a cyclic lower alkyl group, etc.; R2 represents a hydrogen atom, an optionally substituted lower alkyl group, a lower alkoxy group, a lower alkenyl group, a cyclic lower alkyl group, a cyclic lower alkoxy group, etc., which exert an excellent inhibitory activity in human SGLT2, and therefore are useful as drugs for the prevention or treatment of a disease associated with hyperglycemia such as diabetes, diabetic complications or obesity, pharmaceutically acceptable salts thereof or prodrugs thereof, production intermediates thereof and pharmaceutical uses thereof.