CA2437240A1 — Glucopyranosyloxybenzylbenzene derivatives and medicinal use thereof

USPTO Abstract

Glucopyranosyloxybenzylbenzene derivatives represented by the following general formula (I) and pharmacologically acceptable salts thereof which are useful as preventives or remedies for diseases caused by hyperglycemia such as diabetes, complications of diabetes and obesity because of having an improve d oral absorbability and exerting an excellent human SGLT2 activity inhibitory effect (in vivo): (I) wherein P represents hydrogen or a group constituting a prodrug; R1 represents hydrogen, optionally substituted amino, carbamoyl, optionally substituted lower alkyl, optionally substituted lower alkoxy, etc .; R2 represents hydrogen or lower alkyl; and R3 represents optionally substituted lower alkyl, optionally substituted lower alkoxy, optionally substituted lower alkylthio etc.