CA2393737A1 — Compositions containing itraconazole with improved bioavailability and narrow intra- and inter-individual variation of its absorption
Assigned to Dong A Pharmaceutical Co Ltd · Expires 2001-06-14 · 25y expired
What this patent protects
The present invention relates to agent containing itraconazole - with both improved bioavailability, due to higher water-solubility and impressively reduced difference of pH-dependent solubility, and narrow intra- and inter- individual variation of its absorption- and a manufactu…
USPTO Abstract
The present invention relates to agent containing itraconazole - with both improved bioavailability, due to higher water-solubility and impressively reduced difference of pH-dependent solubility, and narrow intra- and inter- individual variation of its absorption- and a manufacturing method thereof. Agent containing itraconazole of the present invention consists of itraconazole, water-soluble macromolecule of 10-100 % w/w to itracotazole, solubilizing agent of 0.1-100 % w/w to itraconazole and pharmaceutically allowed additives. Agent containing itraconazole of the present invention minimizes absorption variation by dozing time after food intake as well as i s available for adults with hypoacidity, AIDS patients and normal people. In addition, the manufacturing method introduces the elementary process, the spray drying, thereby control of physical properties of particles containing drug is easier and economy/production is improved.
Drugs covered by this patent
- Cozaar (LOSARTAN POTASSIUM) · Merck & Co.
Bibliographic data sourced from FDA Orange Book + USPTO public records. Plain-English summary generated by AI grounded in source text. Patent term extensions (PTR, SPC, pediatric) may shift the effective expiry. Not legal advice.
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