CA2338121A1 — Amide derivatives useful as inhibitors of the production of cytokines

USPTO Abstract

The invention concerns amide derivatives of formula (I) wherein R3 is (1- 6C)alkyl or halogeno; Q1 is heteroaryl which is optionally substituted with 1, 2, 3, or 4 substituents such as hydroxy, halogeno, trifluoromethyl, (1- 6C)alkyl, (1-6C)alkoxy, hydroxy-(1-6C)alkyl, (1-6C)alkoxy-(1-6C)alkyl, hydro xy- (2-6C)alkoxy, amino-(2-6C)alkylamino, N-(1-6C)alkyl-(1-6C)alkylamino- (2- 6C)alkylamino, aryl, heteroaryl and heterocyclyl; p is 0-2 and R2 is a substituent such as hydroxy and halogeno; q is 0-4; and Q2 includes optional ly substituted aryl, cycloalkyl, heteroaryl and heterocyclyl; or pharmaceutical ly- acceptable salts or in vivo-cleavable esters thereof; processes for their preparation, pharmaceutical compositions containing them and their use in th e treatment of diseases or medical conditions mediated by cytokines.