CA2280913A1 — 2-piperazinone-1-acetic acid derivatives and their use

USPTO Abstract

The present invention provides compounds and medicines effective for prophylaxis and therapy of various diseases by controlling or inhibiting celladhesion. Especially, the compounds of this invention inhibits platelet aggregation action without remarkable elongation or hemorrhagic period and can be used as a safe and long-acting antithrombotic drug as compared with known substances showing the same activity. Compounds of this invention are piperazinones of formula (I), wherein the ring A is a basic heterocyclic group; the ring B is a nitrogen containing heterocyclic group or a cyclic hydrocarbon group; Y is CH2; R1 is H, OH, NH2 or a hydrocarbon group which may be bound through CO, S, SO or SO2; R2 is H or a hydrocarbon group; R3 is an optionally esterified or amidated carboxyl group; and D is a lower alkyl group substituted with an optionally esterified carboxyl group; or a salt thereof.