CA2265461C — Compositions and methods for topical application of therapeutic agents

USPTO Abstract

The present invention generally relates to pharmaceutical compositions that enable control of drug delivery properties and the development of optimal drug delivery strategies customized for particular drugs and particular diseases. The composition includes a dissolved pharmaceutical that has the capacity to permeate the stratum corne um layer of the epidermis and become available systemically, and pharmaceutical in a microparticulate state that does not readily cross t he stratum corneum of the epidermis. The dissolved and microparticulate pharmaceuticals may be the same or different pharmaceutical s. Methods for the preparation and use of the compositions are also provided. In a preferred embodiment, the invention finds particular use in a formulation for the topical application of dapsone for the treatment of acne. In another preferred embodiment, the invention finds particular use for the treatment of herpes lesions.