CA2143246C — Imidazodiazepines

USPTO Abstract

Imidazodiazepines of the general formula (see formula I) wherein A and the two carbon atoms denoted by .alpha. and .beta. together signify one of the residues (see formula II) Q signifies one of the residues (see formula III) R1 and R2 each signify hydrogen, lower alkyl, lower alkenyl, lower alkynyl, lower hydroxyalkyl, lower alkoxy-lower alkyl, (C3-C6)-cycloalkyl, (C3-C6)-cycloalkyl-lower alkyl, amino-lower alkyl, lower alkylamino-lower alkyl, di-lower alkylamino-lower alkyl or aryl-lower alkyl or together with the nitrogen atom signify a 5- to 8-membered heterocycle optionally containing a further hetero atom or a fused benzene ring, R3 signifies hydrogen and R4 signifies lower alkyl or R3 and R4 together signify a di- or trimethylene group and R5 and R6 each signify hydrogen, halogen, trifluoromethyl, lower alkoxy or nitro, and the carbon atom denoted by .gamma. has the S-configuration when R3 is different from hydrogen, have pronounced anxiolytic, anticonvulsant, muscle relaxant and sedative-hypnotic properties. They form acid addition salts which have very good water solubility and are therefore particularly suitable for the production of aqueous injection solutions.