CA2118985A1 — Heterocyclic inhibitors of farnesyl protein transferase

USPTO Abstract

Abstract HETEROCYCLIC INHIBITORS OF FARNESYL PROTEIN TRANSFERASE Inhibition of farnesyl protein transferase is effected by compounds of the formula its enantiomers, diastereomers, pharmaceutically acceptable salts, prodrugs or solvates thereof, wherein: A1 and A2 are each independently H, alkyl, substituted alkyl, cycloalkyl, substituted cycloalkyl, phenyl or substituted phenyl; G1 is S or O; G2 is H, -C(O)OH, -C(O)NH2, 5-tetrazolyl, -C(O)N(R7)OH or -CH2OH; X is O or R8N; Y and Z are each independently -CH2- or -C(O)-; R1, R2, R3, R4, R5, R6 and R7 are each independently H or alkyl; R1 may also be alkanoyl, R1 and A1 taken together may be -(CH2)m; R8 is H, alkyl, phenyl, phenylalkyl, substituted phenyl, (substituted phenyl)alkyl or -C(O)R9; R9 is H, alkyl, phenyl, phenylalkyl, substituted phenyl or (substituted phenyl)alkyl; m is 3 or 4; n is 0, 1 or 2; p is 0, 1 or 2; and q is 0 or 1, with the proviso that when p is 0, then q is also 0.